Transcriptome provides insights into bovine mammary regulatory mechanisms during the lactation cycle

The molecular events underlying the lactation curve of dairy animals have long been a biological conundrum for mammary biologists, and cause considerable loss income farmers. To better understand regulatory mechanisms developmental processes gland during cycle, whole-genome transcriptome profiles bovine tissues at five different stages were investigated using RNA-Seq technique. differentially expressed genes identified by comparing stage combinations. Gene expression changes validated quantitative reverse-transcription polymerase chain reaction. Some found to locate in known trait loci regions that are associated with multiple milk production traits. Proteins potentially important confirmed be epithelium cows. An integrated analysis differential gene indicated internal development regularities shape curve. First, is enriched similar activities onset involution, but opposite directions. Second, before after peak shared mainly involved extracellular matrix remodelling. discoveries study provide information necessary improve production.